Which of the following statements explain why fructose 2,6-bisphosphate is important in regulating glycolysis in the liver?
1) It activates phosphofructokinase-1, the key regulatory enzyme in glycolysis
2) It inhibits fructose 1,6-bisphosphatase, an enzyme that catalyzes the reverse reaction of phosphofructokinase-1
3) It promotes the conversion of glucose to pyruvate, increasing the production of ATP
4) It stimulates the production of glycogen, which can be broken down to provide glucose for glycolysis