HCRE5424 HCRE5424

21-05-2024
Medicine

Answered

You’ve accidentally consumed a drug that specifically blocks IFN induction of ERAP. Which of the following statements would you expect?
A. Any cytokine stimulation would strongly upregulate ERAP causing ERAP activity to return to normal
B. No MHC Class I presentation would take place, as IFN stimulation is necessary for ERAP activity
C. A decreased IFN stimulation would just decrease efficiency of ERAP due to less stimulation of TAP, a necessary metabolic precursor to ERAP
D. A and C

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