A 55-year-old man has struggled to maintain his blood glucose levels within the target range despite lifestyle modifications and adherence to his medication regimen. He is 55 years old, 95 kg and 178 cm tall. He has a medical history of type 2 diabetes mellitus diagnosed 5 year ago, hypertension, hyperlipidemia. His current medications are metformin, atorvastatin, lisinopril. His HbA1c has consistently been around 8.5%. During his latest visit, his endocrinologist decide to add Ozempic (semaglutide) to his treatment plan.
Describe the role of GLP-1 in glucose homeostasis. How does it influence both insulin and glucagon secretion?
