A 27-year-old woman presents to an emergency department with a chief complaint of blurring of vision in her left eye for the past few days. She denies weakness, urinary incontinence, facial pain, or any other neurologic symptoms. Her past medical history is significant for conversion disorder. Her father has diabetes mellitus type 2 and her mother has hypertension. Physical examination is remarkable for left eye visual acuity of 20/200, left-sided afferent pupillary defect on swinging light test, and a pale optic disc on left eye fundoscopy. A brain MRI with high T2 signaling intensity shows multiple lesions in the supratentorial white matter, but no mass or any other lesions. She is diagnosed with clinically isolated syndrome. The underlying pathogenesis is the development of the autoimmunity against a specific type of neuroglial cells present in the central nervous system. Which of the following cells of visceral afferent Ad-type fibers are functionally most similar to the neuroglial cells targeted by the autoantibody in this patient’s medical condition? A. Astrocytes B. Schwann cells C. Oligodendrocytes D. Microglia



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