LDL Cholesterol in Humans + Statin. Path model: dose of drug= .03(g/d)/1 (mg/d) increases rate of transport of cholrsterol into liver cells = .95(g/d)/1(g/d) increases rate at which enzymes in the liver convert cholesterol to bile salts = -302(mg/dl)/1(g/d) decreases concentration of LDL cholesterol in the blood. What drug dosage (mg/d) must be administered to reduce the concentration of LDL cholesterol in the blood by 60 mg/dL? Note: the drug has no effect on LDL cholesterol in the body at dosages of 4.0 mg/d or less, so be sure to add 4.0 mg/d to your final answer no matter what. Hint: this question requires multiple steps. First, you need to deterkine the change in enzyme activity needed to reduce LDL cholesterol. Then, determine the change in cholesterol trasnpirt rate needed to achieve the change in enzmye activity.