What happens when a nucleotide pairs with the wrong nitrogen base? DNA polymerase pauses the process of DNA replication and initiates a series of steps to correct the problem. Primase sets down an RNA primer that initiates a sequence of events to correct the error. A single nucleotide error is not a problem, so the cell does not have a process to change it. It is simply left in place. Okazaki fragments are formed and inserted to make the correction.