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of the four river valleys that supported major early civilizations, which one lost one of its major rivers



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I'd say Indus Valley. There used to be River Saraswati whose course (bed) has turned to desert now. 
Yellow river is noted for changing course only. The other two (Nile, Shatt-el-Arab being confluence of Euphrates & Tigris) haven't changed course nor got lost.

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