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Sickle-cell anemia is a genetic disorder of the blood in which the shape of red blood cells is distorted, resulting in a variety of health problems. The allele for normal blood cell production (H) is dominant to the allele for sickle cell production (h). If one parent has sickle-cell anemia and the other parent is a carrier, what is the probability that their child will have sickle-cell anemia? A. 100% B. 50% C. 75% D. 25% punnet square H h h ? ? h ? ?



Answer :

B) 50% chance of the child having the disease. 
This is because the parent who is a carrier must have Hh. The parent who has the disease must be hh (as it's a recessive disease, so you can only have it if you have no H).
If you draw this punnet square and fill in the blanks:
   x        H          h
   h

   h

You will get:
1) Top left = Hh (child does NOT have the disease)
2) Bottom left = Hh (child does NOT have the disease)
3) Top right = hh (HAS disease)
4) Bottom right = hh (HAS disease)
Therefore 1 in 2 chance (50%)

Answer:

50%

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