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One molecule that activates a phosphorylation cascade similar to cyclic adenosine monophosphate (cAMP) is cyclic guanosine monophosphate (cGMP). Like cAMP, cGMP is a second messenger involved in intracellular signal transduction. When a ligand binds to its receptor (such as nitric oxide in the case of cGMP), it activates an enzyme called guanylate cyclase, which converts guanosine triphosphate (GTP) into cGMP. cGMP then activates protein kinase G (PKG), which phosphorylates downstream target proteins, leading to various cellular responses.

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