Which of the following is false regarding the GI tract and drug absorption?

A. pH partitioning influences absorption.
B. The presence of food in the stomach or intestine influences absorption.
C. Protein solubility influences absorption.
D. Blood flow influences absorption.



Answer :

Final answer:

The pH of the stomach is the critical factor influencing drug absorption in the gastrointestinal tract.


Explanation:

pH - This is the correct answer.
The most important factor that determines absorption within the stomach is pH. Weak organic acids, which exist in a diffusible, nonionized and lipid-soluble form are readily absorbed in the high acidity of the stomach (pH 1-3). In contrast, weak bases will be highly ionized and therefore poorly absorbed.


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